Weight Loss and Autoimmune Update

I got down to 187 about a week ago…a 25 pound loss from my top weight of 212 in January.  Then I started having a lot of cravings. One thing I’ve learned about myself is that I have a strong backbone when it comes to sticking with a diet or plan that is working for me.  I can refuse my favorite foods every single day for months and months at a time, knowing they’re not currently aligned with my commitment to myself to be healthy.  Maybe that sounds extreme – but to me, it’s focused.  SO…..when I have cravings and can’t stop thinking about food and I’m not hungry, I know it’s not a character issue.  I know something biological is causing it.

In the last week I’ve been having cravings for high-fat food.  When I started my weight loss journey I was eating 2 eggs every day and low-fat cottage cheese in the afternoons.  Since I got diagnosed with Lichen Sclerosus I’ve been trying to follow something closer to the Autoimmune Protocol by removing eggs and dairy from my diet.  This has left me with very very little dietary fat – probably around 10-15g a day.  I guess that’s just too damn low and my body is needing more.  I notice my hair, which I used to have to wash daily due to oiliness, now takes much longer to get oily, and I can now go 2-3 days without washing it.  Anyway, the food cravings have been a bit of a problem so in the last few days I’ve been adding eggs back in (which went fine) and I’ll be adding the cottage cheese back in – I could be missing the nutrients in those foods too.

So for the moment, my weight is back up to 190 – on the upswing because I have been eating things not supportive of my weight loss goals.

Had a doctor’s appointment with my functional med doc a few days ago. He didn’t want to test for Lyme, given the poor reliability of testing (regardless of lab, he says) and the extreme nature of treatment if I do get a positive.  He said that unless I was really feeling terrible it wouldn’t be worth it.  I can’t disagree with that.  He also said that lots of things cause autoimmunity – not just Lyme, and that Lyme isn’t even the most likely culprit.

When I got home from that appointment I saw this article in my Facebook feed: Trigger for Autoimmune Disease Identified, which references this study that was published a couple of months ago.  The basic idea is this:

B cells expressing the transcription factor T-bet promote the rapid appearance of autoantibodies and germinal centers in spontaneous murine models of systemic lupus erythematosus (SLE). Conditional deletion of T-bet from B cells impaired the formation of germinal centers and mitigated the development of kidney damage and rapid mortality in SLE mice.

So the B cells – I guess this is a kind of white blood cell – may or may not be expressing transcription factor T-bet.  The mice that were expressing T-bet and who were genetically susceptible to autoimmunity, had a high rate of autoimmunity.  The susceptible mice who had T-bet deleted from their B cells stayed healthy.

So what causes T-bet expression?

Check this out (h/t to Ruth in my Ray Peat Facebook group): “Prolactin (PRL) exposure stimulates expression of T-bet, an immunoregulatory transcription factor for Th1 development, and alters secreted cytokine profile in peripheral blood mononuclear cells (PBMC)”.

Prolactin = bad.  Just like Ray Peat sez!

Before I go on…a bit of background about prolactin from Self Hacked:

Prolactin is a peptide hormone made by the pituitary gland and various other parts of the body. It is also referred to as the luteotropic hormone (luteotropin) and PRL. Prolactin is encoded by the PRL gene (R).

Primarily, prolactin is responsible for the stimulation of milk production in women (lactogenesis) (R).

When a woman is pregnant, prolactin levels increase by up to 10-20 times the  normal amount.  The levels return to normal within a few weeks after the mother stops breastfeeding.

Despite what its name suggests, prolactin does much more than only promote lactation. It is found in men as well and is influential in over 300 separate processes.  It is recognized as a multipurpose hormone with one of the widest ranges of physiological actions of any hormone (R).

Here are more studies that discuss prolactin’s negative effects on the immune systems (specifically B cells):

Prolactin Alters the Mechanisms of B Cell Tolerance Induction

Prolactin Levels Correlate with Abnormal B Cell Maturation in MRL and MRL/lpr Mouse Models of Systemic Lupus Erythematosus-Like Disease

Prolactin modulates the naive B cell repertoire

Prolactin Rescues Immature B-Cells from Apoptosis Induced by B-Cell Receptor Cross-Linking

What’s interesting to me is that this hormonal connection between Prolactin and autoimmunity may help explain why far more women than men have autoimmune conditions.

So then I googled “What causes high prolactin?”  I know I could burrow through articles at raypeat.com and find this answer but I’m short on time these days.  The Pituitary Society seemed as good a source as any….oh hey look!  The medication I take for hypertension actually INCREASES prolactin!  Awesome…so Verapamil increases histamine release (and thus sustains my hot flashes) and also increases prolactin, perhaps causing and/or sustaining my autoimmune condition.

AWESOME!!!!

Ok, I seriously have to get my blood pressure down.  Immediately.  I need to get off this big pharma rollercoaster.

Fortunately, I have a baseline prolactin level from testing I did 2 years ago, long before starting this medication.  I’m going to get it tested again today to compare.

2 thoughts on “Weight Loss and Autoimmune Update

  1. Well, that’s a BS appraisal of the possibility of Lyme, if I’ve ever heard one. A comment that would only come from someone lacking the ability to diagnose and effectively treat Lyme. Lyme is a huge trigger for autoimmunity. And yes, a standard test will turn up negative. And yes, conventional antibiotic treatment is highly ineffective and would only harm. Get your butt to Grand Rapids, MI, for a two hour consult with Dr. Linda Hegstrand MD, Phd. In two hours, you will know exactly what you have. Even Dr. Amy Yasko has recently delved into the issues of mycoplasma. Dr. Hegstrand identified and cleared me of Lyme, mycoplasma, Bartonella, Babesia, h-pylori and HHV6. Your functional doc is wrong.

  2. Susie – I’m glad you commented. I have actually considered doing just that – it’s just a trip across the lake for me, actually. Can I ask how she diagnosed those things? I’m trying to remember – was it muscle testing? I have hesitated because I have no other Lyme-like problems. No muscle aches or joint problems, no neuro symptoms that I’m aware of, just the Lichen Sclerosus. Can you email me so I can ask more about what you’ve been doing?

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